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2-AG was shown to promote the differentiation of OPCs into mature myelinating oligodendrocytes in primary mixed glial cell cultures from rats through the activation of CB 1 Rs and CB 2 Rs (Gomez et al., 2010)

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Two of these studies found that nicotinamide treatments were more effective in males (PMIDs 8951265, 7660324), whereas two found more striking results in females (PMIDs 34238308, 32320006), with several studies mentioning that larger study sizes would be necessary to properly assess the difference in sex

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